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KMID : 1059520140580040377
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Journal of the Korean Chemical Society
2014 Volume.58 No. 4 p.377 ~ p.380
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Antimicrobial Activities of Novel 3-Substituted [1,2,4] Triazolo[4,3-b]pyridazines Derivatives
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Ruso Jayaraman Sembian
Rajendiran Nagappan
Srinivas Chowdappa
Murthy Konappa Narasimha
Soumya Krishnamurthy
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Abstract
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A noval derivatives of 3-substituted[1,2,4]triazolo[4,3-b]pyridazine (4a-4o) and 7,8,9,10-tetrahydrobenzo[4,5] thieno[2,3-d][1,2,4]triazolo[4,3-b]pyridazine (7a-7l) is prepared by the reaction of heteroaryl hydrazone from the aldehyde and pyridazinohydrazine derivative, followed by subjecting the intermediate directly to oxidative cyclization employing the mixture of Me4NBr and Oxone. These derivatives were subjected to preliminary antimicrobial activities against microorganism. All these compounds exhibit good to moderate activity.
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KEYWORD
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1,2,4 Triazolopyridazine, Aromatic aldehyde antifungal and antibacterial
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